Microelectrods for biosensor applications
In the frame of European Research Projects Scriba developed several non-conventional fabrication techniques for fabricating microelectrodes on different substrates, mainly on flexible substrates, that can be functionalized and used for example in biosensor technology. Background knowledge of infrared printing laser ensures easy achieving of geometries with feature size up to 10 µm, without the need of using processes like UV photolithography.
Scriba performed additive processes, which allows to transfer electrodes on the receiving substrate starting from solutions or inks containing nanoparticles. Electrodes can be patterned with different metals (Gold, Nickel, Platinum, Copper) with different thickness of metallization, on different flexible substrates (polyimide, polypropylene, polyethylene terephthalate, polydimethylsiloxane) or rigid (silicon, glass, metallic substrates).
Microelectrodes can be easily customized with specific parameters of width (W) and length (L), either for interdigitate or linear geometries. Geometry, morphology and surface roughness of microelectrodes can be characterized with atomic force microscopy and optical microscopy. Adherence of metallic layer to substratum is verified with laboratory test and scratch test.
Besides using laser ablation with infrared laser, Scriba can also perform additional processes like:
- Electroplating for modifying work function of electrodes, in a localized manner.
- Functionalization with organic monolayers, using ad hoc formulations.
Manufacture process entirely accomplished in Scriba, allows to achieve all micro-electronic devices in which a high output current is requested, facing low voltage applied, like for example transistors in field effect in water environment for sensing application EGOFET).
Main applications can be:
- Chemical sensors
- Biosensors for detection of biomolecules
- Electrochemical cells
- Electrodes on a biocompatible support for in vitro stimulation
NEW: Scriba can pattern microelectrodes even in conducting polymer like PEDOT:PSS on hydrophilic substrates.
Microelectrodes for biosensor technology
A biosensor can be described as an analytical device that is able to convert a biological signal into a measurable electrical signal. The key features for the biosensor technology are:
- High selectivity
- High sensibility
- Low response time
- Low cost
Scriba microelectrode’s can find application in biosensor technology due to the fact that the microelectrode can be easily functionalized and able to recognize and quantify biological molecules in aqueous media. In addition, Scriba can couple the microelectrodes technology to microfluidic chip to obtain a “lab on chip” device.
Due to its low cost and the possibility of integration in a high-scale industrial production, this device has a big potential to be used in clinic environment, with possible application in the field of early diagnosis.